Heterogeneity of neurotransmitter receptors
نویسندگان
چکیده
منابع مشابه
Synaptic neurotransmitter-gated receptors.
Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin, GABA, and glycine, followed later by similar ...
متن کاملNeurotransmitter receptors on microglia
As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation phenotype and cellular context. A variety of neuro...
متن کاملEndocytosis of Neurotransmitter Receptors: Location Matters
Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is...
متن کاملNeurotransmitter Receptors in the Postsynaptic Neuron
Communication between adjacent neurons in the central nervous system occurs at specialized regions of the nerve cells termed the synapse. It is mediated by themovement of chemical mediators or neurotransmitters across a small gap that exists between the nerve cells. When a neuron is activated, it releases molecules of neurotransmitter from synaptic vesicles localized in the presynaptic terminal...
متن کاملUnderstanding neurotransmitter receptors: molecular biology-based strategies.
Neurotransmitter receptor proteins can be divided into GPCRs and ligand-gated ion channels. Members within each family utilize a similar signalling mechanism and are structurally related. Multiple receptor subtypes are expressed for individual neurotransmitters, generating orders of complexity that have been exploited for therapeutic intervention. GPCRs have been cloned and extensively studied ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39992-5